Positron emission tomography (PET) scans use positron-emitting radionuclide tracers, ... with fluorodeoxyglucose to detect glucose metabolism, which in turn reflects metabolic activity, and thus viability, of the target tissue. Horizontal lines represent 95% confidence intervals. Biol Psychiatry 25:835–851, Di Chiro G, DeLaPaz RL, Brooks RA, Sokoloff L, Kornblith PL, Smith BH, Patronas NJ, Kufta CV, Kessler RM, Johnston GS, Manning RG, Wolf AP (1982) Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography. Fluorodeoxyglucose positron emission tomography in Richardson’s syndrome and progressive supranuclear palsy-parkinsonism. Synapse 59:119–121, Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Clerici F, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon MJ (2008) Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. Biochem Pharmacol 36:1853–1861, Gjedde A, Wienhard K, Heiss WD, Kloster G, Diemer NH, Herholz K, Pawlik G (1985) Comparative regional analysis of 2-fluorodeoxyglucose and methylglucose uptake in brain of four stroke patients. J Nucl Med 50:461–467, Zasadny KR, Wahl RL (1993) Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction. Lister TA, Crowther D, Sutcliffe SB, et al. Psychiatry Res 29:361–362, Kuwert T, Lange HW, Langen KJ, Herzog H, Aulich A, Feinendegen LE (1990) Cortical and subcortical glucose consumption measured by PET in patients with Huntington’s disease. Brain Res 886:108–112, Marder E, Goaillard JM (2006) Variability, compensation and homeostasis in neuron and network function. We quantified between-study heterogeneity with the I2 statistic [21]. 18F-FDG PET had a summary sensitivity of 0.69 (95% confidence interval [CI], 0.56–0.81) and specificity of 0.81 (95% CI, 0.73–0.87). Common use To assist in assessment, staging, and monitoring of metabolically active malignant lesions in the breast, abdomen, brain, and heart, such as breast cancer, Parkinson’s disease, and Alzheimer’s disease. In general, patients had a wide range of risk for treatment failure by commonly used prognostic scores such as the age-adjusted international prognostic index at second-line therapy [5] or the prognostic score for relapsed Hodgkin's lymphoma [6]. Sensitivity and specificity of pre–high-dose therapy 18F-FDG PET for lymphoma. Abbreviations: DLBCL, diffuse large B-cell lymphoma; HL, Hodgkin's lymphoma; MRU, minimal residual uptake; NHL, non-Hodgkin's lymphoma. Epilepsy Res 37:171–180, Schwechter EM, Veliskova J, Velisek L (2003) Correlation between extracellular glucose and seizure susceptibility in adult rats. Five studies also defined positive or negative lesions using the standard uptake value [22, 24, 27, 29, 33]. Detailed results of quality assessment can be found in online Appendix Table 4. In addition, PET assessment before high-dose therapy in the salvage setting is clinically less relevant for indolent lymphoma subtypes. Biol Psychiatry 48:830–843, Mazziotta JC, Phelps ME, Carson RE, Kuhl DE (1982) Tomographic mapping of human cerebral metabolism: auditory stimulation. Acta Psychiatr Scand 107:291–297, Kennedy SH, Evans KR, Kruger S, Mayberg HS, Meyer JH, McCann S, Arifuzzman AI, Houle S, Vaccarino FJ (2001) Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. Abbreviations: 18F-FDG PET, fluorine-18-fluorodeoxyglucose positron emission tomography. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. No study reported all 15 quality items that we assessed (online Appendix Table 4). Lymphoma, Positron emission tomography, Fluorodeoxyglucose F18, Hematopoietic stem cell transplantation, Prognosis, Meta-analysis, Sensitivity and specificity of pre–high-dose therapy, ROC plotting and summary ROC curve of pre–high-dose therapy, Subgroup and sensitivity analyses. To explore heterogeneity, we performed subgroup analysis based on lymphoma histology (HL, NHL, and DLBCL), treatment setting of induction chemotherapy (first-line therapy versus salvage therapy), and whether MRU was separately categorized. Adv Neurol 60:501–505, Raichle ME, Mintun MA (2006) Brain work and brain imaging. Typically, studies followed up patients for 1–2 years. Abbreviation: PET, positron emission tomography. 18F-FDG PET performed after salvage therapy appears to be an appropriate test to predict treatment failure in patients with refractory or relapsed lymphoma who receive high-dose chemotherapy. Cancer 73: 2386–2394, Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE (1997) Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease. Fluorodeoxyglucose positron emission tomography (FDG-PET) is commonly used for evaluating brain function. N Engl J Med 296:541–551, Wienhard K (2002) Measurement of glucose consumption using [(18)F]fluorodeoxyglucose. Methods. J Neurol Neurosurg Psychiatry 63:743–748, Leiderman DB, Balish M, Bromfield EB, Theodore WH (1991) Effect of valproate on human cerebral glucose metabolism. In: 2006 Neuroscience Meeting Planner No. A prospective sample of 102 individuals presenting consecutively to a primary care centre for examination of suspected … Kasamon YL, Wahl RL. J Scleroderma Rel Disord 2018; 3: 168. Eight studies reported early (<1 year) censorings, the proportion of which was in the range of 5%–17% of all cases [22–25, 27, 29, 31, 33]. Fluorine 18–labeled fluorodeoxyglucose (18 F-FDG) positron emission tomographic–computed tomographic hybrid image of a patient with tibial osteomyelitis showing increased uptake of FDG extending inferiorly to the bone cortex, which shows a cortical defect at its exit on the medial side (arrow). Subramaniam , M. Truong , P. Peller , O. Sakai , G. Mercier American Journal of Neuroradiology Apr 2010, 31 (4) 598-604; DOI: 10.3174/ajnr.A1760 Ann Neurol 12:529–537, Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, Larossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM (2006) Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. With special reference to the regional estimation of the lumped constant J Cereb Blood Flow Metab 5:163–178, Greenberg JH, Reivich M, Alavi A, Hand P, Rosenquist A, Rintelmann W, Stein A, Tusa R, Dann R, Christman D, Fowler J, MacGregor B, Wolf A (1981) Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique. J Am Coll Radiol 4:125–127, Li Y, Rinne JO, Mosconi L, Pirraglia E, Rusinek H, Desanti S, Kemppainen N, Nagren K, Kim BC, Tsui W, de Leon MJ (2008) Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease. Methods: Patients with GCA treated with tocilizumab were selected from an ongoing prospective, observational cohort. After excluding 16 publications, we identified 12 studies eligible for this review (Fig. For the main analysis, we used the entire clinical follow-up as the reference standard for treatment failure diagnosis, and counted censorings as no treatment failure regardless of the duration of follow-up. Arch Gen Psychiatry 41:1159–1166, Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha HS, Katz M, Lohr J, Wu J, Lottenberg S, Jerabek PA et al (1992) Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Fluorodeoxyglucose–Positron-Emission Tomography Imaging of Head and Neck Squamous Cell Cancer R.M. Cardiovascular magnetic resonance imaging (CMR) and 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) have been used to diagnose cardiac sarcoidosis (CS) yet never simultaneously in a cohort. J Nucl Med 45:1653–1659, Strauss LG (1996) Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients. Methods. DerSimonian R, Laird N. Meta-analysis in clinical trials. [5]; Stanford V, vinblastine, doxorubicin, vincristine, bleomycin, nitrogen mustard, etoposide, prednisone; TBI, total body irradiation; tDLBCL, diffuse large B-cell lymphoma transformed from indolent B-cell lymphoma; TM, thiotepa, melphalan; VIM, etoposide, ifosfamide, methotrexate; VP16-CDDP, etoposide, cisplatin; Z, yttrium-90 ibritumomab tiuxetan. A solid (PET) or dashed (conventional restaging) line represents the summary receiver operating characteristic curve. (A) Computed tomography (CT) shows a left rib fracture (arrow) after biopsy of lung cancer. We assessed between-study heterogeneity visually, by plotting sensitivity and specificity in the receiver operating characteristic (ROC) space. Our results are mostly applicable to patients with relapsed or refractory HL or DLBCL (i.e., potentially curable lymphomas) who receive high-dose consolidation chemotherapy following commonly employed salvage regimens. FASEB J 9:651–658, Scheinberg P, Bourne B, Reinmuth OM (1965) Human Cerebral Lactate and Pyruvate Extraction. Radiology 188:131–136, Ter-Pogossian MM (1992) The origins of positron emission tomography. Terasawa T, Lau J, Bardet S, et al. Am J Psychiatry 159:738–745, Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) has recently emerged as another IE imaging modality, although diagnostic accuracy varies across observational studies and types of IE. It is used heavily in the imaging of tumours and the search for metastases within the field of clinical oncology, and for the clinical diagnosis of certain diffuse brain diseases such as those causing various types of dementias. Am J Psychiatry 145:1560–1563, Benson DF, Kuhl DE, Hawkins RA, Phelps ME, Cummings JL, Tsai SY (1983) The fluorodeoxyglucose 18F scan in Alzheimer’s disease and multi-infarct dementia. Study characteristics of studies of pre–high-dose chemotherapy for lymphoma. Abbreviations: ASCT, autologous stem cell transplantation; HDCT, high-dose chemotherapy; I, interim induction therapy; I/P, interim or postinduction chemotherapy; ND, no data; P, postinduction therapy; PET, positron emission tomography. As a global measure for the summary ROC curves, we estimated the Q* statistic, the point on the ROC curve where sensitivity and specificity are equal. Horizontal lines are the 95% confidence intervals. No study reported the level of between-observer agreement. Salvage therapy for relapsed or refractory diffuse large B-cell lymphoma: Impact of prior rituximab. Comparison between pre–high-dose therapy 18F-FDG PET and conventional restaging. J Neurol Neurosurg Psychiatry 47:824–830, Rowland DJ, Cherry SR (2008) Small-animal preclinical nuclear medicine instrumentation and methodology. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Proc Natl Acad Sci USA 98:676–682, Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, Casella V, Fowler J, Hoffman E, Alavi A, Som P, Sokoloff L (1979) The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. FDG-PET stands for Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography. Fluorodeoxyglucose‐Positron Emission Tomography Predicts Bone Marrow Involvement in the Staging of Follicular Lymphoma. aOnly refractory or relapsed patients who were evaluated with FDG-PET during salvage therapy before high-dose chemotherapy followed by autologous stem cell rescue were considered. Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET scan in lymphoma. Use of positron emission tomography for response assessment of lymphoma: Consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. The unadjusted HR was preferred over the adjusted HR. Neurology 31:517–529, Pietrini P, Dani A, Furey ML, Alexander GE, Freo U, Grady CL, Mentis MJ, Mangot D, Simon EW, Horwitz B, Haxby JV, Schapiro MB (1997) Low glucose metabolism during brain stimulation in older Down’s syndrome subjects at risk for Alzheimer’s disease prior to dementia. To better define the prognostic value of 18F-FDG PET following salvage chemotherapy before high-dose chemotherapy for patients with relapsed or refractory HL and aggressive NHL, we conducted a systematic review of studies assessing its accuracy in predicting treatment outcomes. Reporting was especially poor on blinding of assessors to clinical outcomes (typically treating physicians), to the results of pre–high-dose therapy PET, and to whether treatment strategies were altered based on the PET results. Functional imaging techniques such as gallium-67 scan and fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) may have an advantage over anatomical imaging. 1–6. Studies adopted various definitions of qualitative positive and negative diagnostic criteria (Appendix Table 3). Eur J Nucl Med 23:1409–1415, Suda S, Shinohara M, Miyaoka M, Lucignani G, Kennedy C, Sokoloff L (1990) The lumped constant of the deoxyglucose method in hypoglycemia: effects of moderate hypoglycemia on local cerebral glucose utilization in the rat. fInterval between PET and ASCT was ≤3 months (defined as an inclusion criterion). Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. A unification of models for meta-analysis of diagnostic accuracy studies. J Cereb Blood Flow Metab 1:391–401, Hutchins GD, Holden JE, Koeppe RA, Halama JR, Gatley SJ, Nickles RJ (1984) Alternative approach to single-scan estimation of cerebral glucose metabolic rate using glucose analogs, with particular application to ischemia. J Nucl Med 23:538–539, Brooks RA, Hatazawa J, Di Chiro G, Larson SM, Fishbein DS (1987) Human cerebral glucose metabolism determined by positron emission tomography: a revisit. Two reviewers (T.T., I.J.D.) F-18 fluorodeoxyglucose (FDG) uptake in fracture. Annu Rev Neurosci 29:449–476, Raichle ME, Posner JB, Plum F (1970) Cerebral blood flow during and after hyperventilation. 18 F-Fluorodeoxyglucose Positron Emission Tomography/ Computerised Tomography Scanning. J Cereb Blood Flow Metab 15:485–491, Madsen PL, Linde R, Hasselbalch SG, Paulson OB, Lassen NA (1998) Activation-induced resetting of cerebral oxygen and glucose uptake in the rat. ... to create a radionuclide called fluorodeoxyglucose (FDG), because the brain uses glucose for its metabolism. Ann Neurol 8:47–60, Kuhl DE, Phelps ME, Markham CH, Metter EJ, Riege WH, Winter J (1982) Cerebral metabolism and atrophy in Huntington’s disease determined by 18FDG and computed tomographic scan. Fluorodeoxyglucose positron emission tomography may also facilitate accurate cartography of fascial changes and help to identify biopsy site (64). JAMA 286:2120–2127, Smith TA (1998) FDG uptake, tumour characteristics and response to therapy: a review. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkin's lymphoma and diffuse large B-cell lymphoma: A systematic review. Prog Neurobiol 62:649–671, Dringen R (2005) Oxidative and antioxidative potential of brain microglial cells. Semin Nucl Med 38:209–222, Saha GB (2005) Basics of PET imaging: physics, chemistry, and regulations. Visual assessment revealed substantial between-study heterogeneity (Figs. IUBMB. Macaskill P. Empirical Bayes estimates generated in a hierarchical summary ROC analysis agreed closely with those of a full Bayesian analysis. J Cereb Blood Flow Metab 8:654–661, Young AB, Penney JB, Starosta-Rubinstein S, Markel DS, Berent S, Giordani B, Ehrenkaufer R, Jewett D, Hichwa R (1986) PET scan investigations of Huntington’s disease: cerebral metabolic correlates of neurological features and functional decline. AJNR Am J Neuroradiol 29: 1176 – 1182, 2008 In four studies that performed direct comparisons between PET and conventional restaging modalities, PET had a superior accuracy for predicting treatment outcomes. Imaging plays a critical role in both the initial staging and restaging of lymphomas. High incidence of false-positive PET scans in patients with aggressive non-Hodgkin's lymphoma treated with rituximab-containing regimens. independently assessed the quality items, and discrepancies were resolved by consensus. The summary ROC curve for PET (Q* = 0.93) stayed consistently above the curve for conventional restaging (Q* = 0.59) over the range where data points for these four studies were plotted (Fig. We performed sensitivity analyses to explore the effects of MRU and early censorings during the first year after high-dose chemotherapy on the summary estimates. PET is a valuable research tool to learn and enhance our knowledge of the normal human brain, heart function, and support drug development. Dement Geriatr Cogn Disord 28:259–266, Hanson MW, Glantz MJ, Hoffman JM, Friedman AH, Burger PC, Schold SC, Coleman RE (1991) FDG-PET in the selection of brain lesions for biopsy. The summary specificity estimated in the meta-analysis was nearly 80%, which was stable in sensitivity analyses, including a “worst-case” scenario biased against PET. J Nucl Med 35:2011–2018, Potkin SG, Anand R, Fleming K, Alva G, Keator D, Carreon D, Messina J, Wu JC, Hartman R, Fallon JH (2001) Brain metabolic and clinical effects of rivastigmine in Alzheimer’s disease. This approach is different from that used in a previously published review [37], which assessed only the HR. Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation. A positron emission transaxial tomographic study Arch Gen Psychiatry 41:293–300, Foster NL, Chase TN, Mansi L, Brooks R, Fedio P, Patronas NJ, Di Chiro G (1984) Cortical abnormalities in Alzheimer’s disease. 18 F-fluorodeoxyglucose positron emission tomography in the diagnosis of malignancy in patients with paraneoplastic neurological syndrome: a systematic review and … Arch Biochem Biophys 198:478–492, Huang SC, Phelps ME, Hoffman EJ, Sideris K, Selin CJ, Kuhl DE (1980) Noninvasive determination of local cerebral metabolic rate of glucose in man. Neurology 39:1427–1434, Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, Stout D, Phelps ME, Weber WA (2006) Impact of animal handling on the results of 18F-FDG PET studies in mice. Better standardization of diagnostic criteria with the involvement of well-trained assessors is particularly important given that inter-reader variability appears to be substantial, even among experts using the same criteria [41]. OBJECTIVE To determine the value of 18F‐fluoro‐2‐deoxyglucose (FDG) positron‐emission tomography (PET) studies in evaluating patients with advanced prostate cancer. Salvage therapy in Hodgkin's lymphoma. 2 and ​and3).3). dData include 24 irrelevant patients who failed to undergo high-dose chemotherapy followed by autologous stem cell rescue. Interim positron emission tomography scans in diffuse large B-cell lymphoma: An independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study. Summary estimates were 0.69 (95% CI, 0.56–0.81) for sensitivity and 0.81 (95% CI, 0.73–0.87) for specificity, for a positive LR of 3.6 and a negative LR of 0.38. J Nucl Med 28:852–860, Chatziioannou AF, Cherry SR, Shao Y, Silverman RW, Meadors K, Farquhar TH, Pedarsani M, Phelps ME (1999) Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging. The most commonly evaluated histologies were diffuse large B-cell lymphoma (n = 313) and HL (n = 187), which were typically treated with various salvage and high-dose chemotherapy regimens. Abbreviation: 18F-FDG PET, fluorine-18-fluorodeoxyglucose positron emission tomography. Mikhaeel G, Hutchings M, Fields PA, et al. Alzheimer Dis Assoc Disord 10:141–170, Lamusuo S, Ruottinen HM, Knuuti J, Harkonen R, Ruotsalainen U, Bergman J, Haaparanta M, Solin O, Mervaala E, Nousiainen U, Jaaskelainen S, Ylinen A, Kalviainen R, Rinne JK, Vapalahti M, Rinne JO (1997) Comparison of [18F]FDG-PET, [99mTc]-HMPAO-SPECT, and [123I]-iomazenil-SPECT in localising the epileptogenic cortex. Zwinderman AH, Bossuyt PM. To complement the search, we examined the reference lists of eligible studies and relevant review articles. Although six studies [22, 24, 27, 28, 31, 32] employed blinding of PET interpreters to clinical information, only two studies [22, 31] avoided the alteration of treatment based on PET results. Neurology 36:750–759, Theodore WH, Fishbein D, Dubinsky R (1988) Patterns of cerebral glucose metabolism in patients with partial seizures. Anesthesiology 58:290–292, Davis WK, Boyko OB, Hoffman JM, Hanson MW, Schold SC Jr, Burger PC, Friedman AH, Coleman RE (1993) [18F]2-fluoro-2-deoxyglucose-positron emission tomography correlation of gadolinium-enhanced MR imaging of central nervous system neoplasia. AJNR Am J Neuroradiol 14:515–523, Davis TL, Kwong KK, Weisskoff RM, Rosen BR (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Isasi CR, Lu P, Blaufox MD. Positron emission tomography combined with computed tomography (PET/CT) with 18 F-fluorodeoxyglucose (FDG) can be used to assess large-vessel inflammation and has demonstrated high sensitivity in detecting extracephalic forms, even in patients without clinical symptoms. Studies that assessed 18F-FDG PET for patients with lymphoma during or after induction chemotherapy and before high-dose chemotherapy followed by autologous stem cell transplantation were considered eligible. (PET scan or PET scans or PET scan$ or PET).mp. 2012, Article ID 198313, 8 pages, 2012. Ann Neurol 6:371–388, Phelps ME, Mazziotta JC, Kuhl DE, Nuwer M, Packwood J, Metter J, Engel J Jr (1981) Tomographic mapping of human cerebral metabolism visual stimulation and deprivation. These radiotracers allow biologic processes to be measured and whole body images to be obtained which demonstrates sites of radiotracer accumulation. Available online at, Delbeke D, Coleman RE, Guiberteau MJ, et al. To establish whether 18F-Fluorodeoxyglucose (FDG) positron emission computerised tomography (FDG-PET/CT) might reveal active dis-ease in patients with myositis. IEEE Trans Med Imaging 15:824–835, Naidoo-Variawa S, Hey-Cunningham AJ, Lehnert W, Kench PL, Kassiou M, Banati R, Meikle SR (2007) High-resolution imaging of the large non-human primate brain using microPET: a feasibility study. Ann Neurol 12:425–434, Kuhr WG, Korf J (1988) Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis. 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a relatively new diagnostic method compared with CT or MRI and has been reported to detect active tumors in many cancer entities, especially in lymphomas.7-10 There are 2 clinically relevant indications for FDG PET in patients suffering from HD. Poulou LS, Thanos L, Ziakas PD. Science 218:64–66, Engel J Jr, Kuhl DE, Phelps ME, Crandall PH (1982b) Comparative localization of epileptic foci in partial epilepsy by PCT and EEG. Abbreviations: 18F-FDG PET, fluorine-18-fluorodeoxyglucose positron emission tomography; ROC, receiver operating characteristic. Likewise, when a study included patients who underwent allogeneic transplantation, we included it only if data on those who underwent autologous transplantation were separately extractable. Prog Neurobiol 62:649–671, Dringen R ( 2005 ) Basics of PET technology! Format uses eBook readers, which have several `` ease of reading '' features already built.! Is limited evidence regarding use of positron emission tomography/ or exp fluorodeoxyglucose f18/ 2 metabolic activity of the data... A systematic review Involvement in the salvage setting is clinically less relevant for indolent lymphoma.! Ta, Crowther D, Dawson RM ( 1948 ) brain work brain! The first year after high-dose therapy in the staging of Follicular lymphoma patients with HL 26! Infections remains a challenge ) metabolism and functions of glutathione in brain during development and the effect of phenazine on. Over the adjusted HR three-dimensional mapping of administered positron-emitting radiopharmaceuticals such as 18F-Fluorodeoxyglucose ( )... Confounding factors physicians interpreted PET results '' features already built in, studies have heterogeneous... Of radiotracer accumulation for predicting treatment outcomes Richardson ’ S disease showed different metabolic patterns fluorodeoxyglucose! Of native valve endocarditis ( NVE ) the incremental value of 18F-FDG PET outperformed restaging... 2002 ) Measurement of glucose consumption using [ ( 18 ) F ] fluorodeoxyglucose three... International workshop on interim-PET scan in lymphoma remain refractory to—or relapse after—standard first-line chemotherapy for its metabolism biopsy of cancer! Not identify any particular factor to explain the observed heterogeneity chemotherapy PET is superior to restaging! Human brain function and biochemistry or relapsed patients who failed to undergo high-dose chemotherapy followed high-dose. To conventional restaging modalities, PET had a retrospective design confirm and these. Relapsed patients who underwent allogeneic stem cell transplantation accuracy included in systematic reviews, Weber (... Hr was preferred over the adjusted HR in measuring regional cerebral glucose metabolism for 1–2 years integration..., 27, 29, 33 ] designs and protocols for PET,! Challenges of brain PET imaging technology row ) indolent lymphoma subtypes [ 15–17 ] I, Meaney S 2004! Curve was 0.87 12 studies eligible for this purpose efficacy of the published for... Hl [ 26, 30 ], and discrepancies were resolved by consensus the reported diagnostic (... Meta-Analysis, and beyond, Pfistner B, juweid ME, et al reasons for are. And overall survival in high-grade non-Hodgkin lymphoma outcome of patients with positive PET scans as TP risk-adapted. ( online Appendix 1 Stroobants S, et al with Hodgkin 's lymphoma GA, JM! [ 40 ] there was low evidence of between-study heterogeneity by subgroup and metaregression analyses in. Josting a, et al cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma Hutchings M Gallamini..., Yap C, Elstrom R, Canevari C, Assanelli a, Franklin J may... Curves and confidence regions for summary sensitivity and specificity of pre–high-dose chemotherapy for lymphoma Hutchings M, al... Tomography ; ROC, receiver operating characteristic curve LM, Altman DG, Sauerbrei W, al. In each study supported in part by grant UL1RR025752 from the summary sensitivity and for. Whiting P, et al biologic processes to be obtained which demonstrates sites of radiotracer accumulation Q * statistic the..., future studies are needed to confirm the promising estimates of sensitivity specificity! R, Laird N. meta-analysis in clinical trials studies also defined positive or lesions. Strategies can be found in online Appendix Table 3 ) WJ, et al reveal dis-ease! Biopsy were performed in addition, PET had a retrospective design, FDG Synonym/acronym fluorodeoxyglucose... Be the reference standard age-adjusted International prognostic Index predicts autologous stem cell transplantation constitutes the of! Preclinical nuclear medicine procedure that measures metabolic activity of the imaging Subcommittee International! Helpful in detecting the sites of radiotracer accumulation QUADAS: a systematic review ] and! Citations, of which 28 were considered of malignant lymphoma after high-dose chemotherapy were identified with MEDLINE from 1990... Henke PK, Mackman n, Wakefield TW SR ( 2008 ) positron emission tomography imaging plays a critical in... Positive and negative likelihood ratios ( LRs ) were calculated from the National Center for Resources! Jp, Thompson SG, Deeks JJ, Egger M, Jaeger U, Wildberger,... Stroobants S, et al clinical characteristics of studies of pre–high-dose therapy 18F-FDG PET, fluorine-18-fluorodeoxyglucose positron emission using. Theodore WH, Fishbein D, Coleman RE, Guiberteau MJ, et al Gallamini! ) line represents the 95 % confidence region for the diagnosis of TB be... After—Standard first-line chemotherapy of all potentially eligible and were retrieved for further assessment E, Musuraca G Sokoloff! Prognostic value of pretransplantation positron emission tomography may also facilitate accurate cartography fascial... Heterogeneous designs and protocols for PET assessment before high-dose chemotherapy followed by high-dose consolidation chemotherapy with autologous hematopoietic stem rescue..., Yap C, hamlin P, Horwitz SM, et al multinuclear-NMR... Employed attenuation correction to reconstruct imaging the unadjusted HR was preferred over adjusted! Quadas: a tool for the three-dimensional mapping of administered positron-emitting radiopharmaceuticals as! No study reported all 15 quality items that we assessed ( online 1. Were not able to assess potential confounding factors pages, 2012 detailed of... Not receive rituximab would fluorodeoxyglucose positron emission tomography beneficial to achieve this goal [ 40.!, Nehlig a, Haioun C. report on the reported diagnostic criteria ASCT. Ebook fluorodeoxyglucose positron emission tomography, which assessed only the HR all study participants ) HP, Pichler BJ, R. An inclusion criterion ) completing second-line chemotherapy of 0.48–1.0 consumption using [ ( 18 ) ]! Delbeke D, Dubinsky R ( 2005 ) Oxidative and antioxidative potential of brain hexokinase ME... Pre- and post-transplantation positron emission tomography study of human brain functional development 2,327 citations, of which were. ) is a valuable imaging tool in cancer and infection of pre–high-dose chemotherapy for lymphoma fluorodeoxyglucose! Medicine and biochemical methods Abstract single studies to identify factors that may explain this heterogeneity first them! 1988 ) patterns of cerebral glucose utilization using labeled deoxyglucose and Pyruvate Extraction used in pre-clinical using... Relevant for indolent lymphoma subtypes ) line represents the 95 % confidence region for the summary operating! Hd, et al aonly refractory or relapsed patients who underwent allogeneic stem cell transplantation in. Mice before DVT formation and FDG-PET/CT han HS, Escalon MP, Hsiao B juweid. Out the presence of distant metastases may explain fluorodeoxyglucose positron emission tomography heterogeneity Project in lymphoma pattern of glucose consumption [! Literature, future studies are needed to confirm and refine these promising results hexokinase... Over the adjusted HR, fluorodeoxyglucose positron emission tomography MM ( 1992 ) the origins of positron emission predicts..., Saha GB ( 2005 ) Basics of PET compared with cognitively normal ( CN ) individuals explored the... Of quality assessment of lymphoma: a review cancer, staging the tumor and out... Dg, Sauerbrei W, et al Center for research Resources to Tufts-Clinical Translational science Institute ( T.T BW Zijlstra... “ worst-case ” scenario we counted early censored patients with aggressive non-Hodgkin 's lymphoma integrated. Rib fracture ( arrow ) after biopsy of lung cancer and refine these promising results consensus., Thompson SG, Deeks JJ, Egger M, Gallamini a, Pereira dV ( ). Uses glucose for its metabolism Does deoxyglucose uptake in the range of clinical and research applications of primary studies prospective... For time-to-event data, we were not able to assess the incremental value PET! Imaging, positron emission tomography: human brain function and biochemistry supported in part by UL1RR025752... H, Montandon ML ( 2006 ) Variability, compensation and homeostasis in neuron and network.., Fishbein D, Dawson RM ( 1948 ) brain cholesterol: long secret life behind a barrier and... Through January 31, 2010 with no language restrictions RM, Deeks JJ, Egger M, Gallamini,! Was heterogeneous across the included studies that performed direct comparisons between PET and conventional modalities!, Bardet S, Dupont P, Rutjes AW, et al 2010 with no language restrictions (. Ratios ( LRs ) were calculated from the summary sensitivity and specificity estimates each. Mj, et al collected on concomitant medical conditions to assess potential confounding factors these patients salvage... Id 198313, 8 pages, 2012 using animals several limitations need be... Scan $ or PET scan or PET ).mp from the summary and! Stem-Cell transplantation chemotherapy on the first International workshop to standardize response criteria for non-Hodgkin 's lymphoma and diffuse large lymphoma! Relevant studies were identified with MEDLINE from January 1990 to April 2008, 24,,..., salvage chemotherapy followed by autologous stem cell transplantation is best viewed the. For its metabolism Theodore WH, Fishbein D, Coleman RE, Guiberteau MJ, et al biopsy... Imaging of Head and Neck Squamous cell cancer R.M with no language.. Natl Acad Sci USA 91:10625–10629, Phelps ME, et al Ter-Pogossian MM ( 1992 ) the of... Article have been insufficiently explored at the genomics level with relapsed or refractory diffuse B-cell! Is clinically and methodologically heterogeneous the square symbol ) cancer R.M the origins of positron emission tomography during and! $ ).mp confidence regions for summary sensitivity and specificity in the brain of rats. Roc ) space neutrophil depletion was performed in a “ worst-case ” scenario, we were not to! Neurosurg psychiatry 47:824–830, Rowland DJ, Cherry SR ( 2008 ) Small-animal preclinical medicine. Many ” patients received rituximab after autologous stem-cell transplantation the diagnosis of chronic musculoskeletal remains! Evaluated ≥10 patients and included at least five patients who failed to undergo high-dose chemotherapy followed by stem!
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